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A solar flare melts the hammer while somehow not burning any of the rest of the solar system.

Starlifting creates and consumes solar flares for energy.

Thanos uses the infinity gauntlet to end the process of starlifting.

Doctor Doom obliterates Thanos.

Highlighting only "Doom" to open up the possibility of someone thinking of a weakness for the concept doom itself. Using specific characters seems limited anyway.

Video gamers beat the landmark classic FPS DOOM.

Video games are made illegal across the world with the offense being punishable by death.

Video games are made illegal across the world with the offense being punishable by death.

Make sure that you make it clear what the specific thing you want defeated is, otherwise the game doesn't work.

Life extension technologies defeat death.

A new disease causes all of the intelligent people in the world to die off which prevents the life extension technology from being used.

Vaccines stop the disease from spreading. (If you're wondering how the vaccine was developed when all the intelligent people have died off, the answer is handwavium. Or quarantine + making the vaccine before dying off completely.)

The events from the movie 2012 destroy all vaccines.

The movie 2012 is struck by a whole basket of Rotten Tomatoes.

Rotten Tomatoes is revealed to be an Onion subsidiary like Clickhole and Patriothole.

Financial failure brings...actually, what does it bring down? The revelation, the Onion or Patriothole? Whatever, it brings them all down.

Trade wars are good and easily end financial failures.

The events of X-Men Apocalypse and Marvel's Infinity War end trade wars.  At least temporarily.