I mean, the important thing to suss out is the structuring of it.
Is this like a cape punk world where superpowers have existed for a long time, or where the powers are just beginning to emerge en masse?
Are superheroes considered just vigilantes, and so criminals of a sort, or does (at least local) government cooperate with them?
Is there some knowledge of a wider multiverse (e.g. Galactus, Thanos, Nova Corps style stuff), or is it very restricted to Earth and Earth's problems?
Is Reed Richards useless, or has he fixed a lot of problems?
Superhumans first started to appear around the same time as the first comic books, in the 1920s/1930s. They exist at a literally one in a million rate that grows with population. The United States, as a result of its population and first world media-soaked nature, has the highest population of known supers, but it is suspected that India and China have more that have simply not been found yet. As such, superpowers are known to exist and, while news about superheroes and villains is rare, it's certainly not unheard of.
As for superheroes, it really depends. The United States federal government instituted the Super Corps back in the 1950's as a way to make use of and keep tabs on patriotic superhumans while allowing them to do varying degrees of good work, and many other nations and alliances (including the European Union, NATO, USSR/Russia, and China) have followed suit. The CIA is also rumored to be involved with communicating and gang-pressing supers, but exactly how or why they do this is unknown. In the United States, independent superhero organizations such as the Boston-Washington Justice Alliance, Great Lakes League, and the Pacific Powers Coalition are allowed to exist, but are frequently the targets of police/Super Corps raids and class-action lawsuits when their operations get too destructive. The degree to which local governments work with the superheroes varies wildly, with some police departments operating on (federally illegal) orders to shoot superhumans on sight if they're near a crime scene (like how the NYPD treats Spider-Man but worse), and other police working closely, publicly, and regularly with superheroes who live nearby (like how old-school Metropolis treats old-school Superman). Most police just stay out of their way, taking help where they need it unless the superhero suddenly turns violent or gets too many cases in court thrown out. Some known superhumans are even in various police departments themselves, allowing easy access to a network of crime and disaster response while giving them some legal shielding. There has been an increase in lone-wolf vigilantism among the super community, however, causing concern for both the almost entirely human government and the struggling superhero leagues.
The RP is restricted to one planet in one universe. I've been wondering if I could fit in a cosmic subplot with conspiracy theory fodder (like a underground war between the Majestic Twelve, the Illuminati, the Knights Templar, and several criminal and political "ghosts"), but nothing truly timey-wimey or multiverse-y.
Reeds Richards is useful, but is frequently the target of (sometimes necessary, sometimes not) government regulation, assassination, warfare or fraud and theft, often orchestrated by similar power hungry Reed Richards. It's often a zero sum game with those guys.